Spanish translation, retranslation, and content validation of the Quality of Life in Alzheimer's Disease scale in patients with Alzheimer's dementia. / Traducción al español, retraducción y validación de contenido de la escala Quality of Life in Alzheimer's Disease en pacientes con demencia Alzheimer.

Introduction: It is estimated that by the year 2050, persons over 60 will account for 22% of the world population. Consequently, the incidence and prevalence of Alzheimer's disease will increase correspondingly. One of the pillars of the treatment of this condition is to improve the quality of life. In this sense, questionnaires such as the Quality of Life in Alzheimer's Disease allow us to measure the quality of life in patients and caregivers. Objective: To translate into Chilean Spanish and carry out the content validation of the Quality of Life in Alzheimer's Disease scale in patients with Alzheimer's dementia at the Guillermo Grant Benavente Hospital in Concepción, Chile. Methods: Translation, back-translation and content validity were carried out by expert judgment, using Lawshe analysis, pre-test and semantic validation using the respondent debriefing strategy. Results: The translated and retranslated versions were compared with each other and with the original version. Lawshe indicates that a Content Validity Ratio equal 0.49 is adequate to consider the item valid when 15 experts participated in the content validation process, as in our study. The analysis yielded a content validity ratio greater than 0.49 in 11 of the 13 items on the scale. Of these, 8 obtained a value greater than 0.8 and 3 between 0.49 and 0.79. In semantic validation using the respondent debriefing strategy, the scale was applied to five people with Alzheimer's and their respective caregivers. With the data obtained, modifications were generated in those items that obtained a content validity ratio of less than 0.49. Conclusions: The version obtained in Spanish of the Quality of Life in Alzheimer's Disease scale is valid from the point of view of its content and equivalent to its original version.

Introducción: Se estima que para el año 2050 los mayores de 60 años corresponderán al 22% de la población mundial y con ello aumente la incidencia y prevalencia de enfermedad de Alzheimer. Uno de los pilares del tratamiento de esta condición es mejorar la calidad de vida, en este sentido surgen herramientas como la Quality of Life in Alzheimer's Disease Scale que permite medir calidad de vida en pacientes y sus cuidadores. Objetivo: Realizar la traducción al español chileno y validación de contenido de la Quality of Life in Alzheimer's Disease Scale en pacientes con demencia por Alzheimer del Hospital Guillermo Grant Benavente de Concepción, Chile. Métodos: Se llevó a cabo la traducción, retraducción y validez de contenido por juicio experto, utilizando el análisis Lawshe, pre-test y validación semántica usando la estrategia de respondent debriefing. Resultados: Las versiones traducidas y retraducidas fueron comparadas entre ellas y con la versión original. Lawshe indica que una razón de validez de contenido de 0,49 es adecuado para considerar aceptable el ítem cuando en el proceso de validación de contenido han participado 15 expertos como en este estudio. El análisis arrojó una razón de validez de contenido mayor a 0,49 en 11 de los 13 ítems de la escala. De estos, ocho obtuvieron un valor superior a 0,8 y tres entre 0,49 y 0,79. En la validación semántica mediante la estrategia de se aplicó la escala a cinco personas con enfermedad de Alzheimer y a sus respectivos cuidadores. Con los datos obtenidos, se generaron modificaciones en aquellos ítems que obtuvieron una razón de validez de contenido menor a 0,49. Conclusión: La versión obtenida en español de la resulta ser válida desde el punto de vista de su contenido y equivalente a su versión original.

Traducción al español, retraducción y validación de contenido de la escala Quality of Life in Alzheimer's Disease en pacientes con demencia Alzheimer / Spanish translation, retranslation, and content validation of the Quality of Life in Alzheimer's Disease scale in patients with Alzheimer's dementia

Introducción Se estima que para el año 2050 los mayores de 60 años corresponderán al 22% de la población mundial y con ello aumente la incidencia y prevalencia de enfermedad de Alzheimer. Uno de los pilares del tratamiento de esta condición es mejorar la calidad de vida, en este sentido surgen herramientas como la Quality of Life in Alzheimer's Disease Scale que permite medir calidad de vida en pacientes y sus cuidadores. Objetivo Realizar la traducción al español chileno y validación de contenido de la Quality of Life in Alzheimer's Disease Scale en pacientes con demencia por Alzheimer del Hospital Guillermo Grant Benavente de Concepción, Chile. Métodos Se llevó a cabo la traducción, retraducción y validez de contenido por juicio experto, utilizando el análisis Lawshe, pre-test y validación semántica usando la estrategia de respondent debriefing. Resultados Las versiones traducidas y retraducidas fueron comparadas entre ellas y con la versión original. Lawshe indica que una razón de validez de contenido de 0,49 es adecuado para considerar aceptable el ítem cuando en el proceso de validación de contenido han participado 15 expertos como en este estudio. El análisis arrojó una razón de validez de contenido mayor a 0,49 en 11 de los 13 ítems de la escala. De estos, ocho obtuvieron un valor superior a 0,8 y tres entre 0,49 y 0,79. En la validación semántica mediante la estrategia de se aplicó la escala a cinco personas con enfermedad de Alzheimer y a sus respectivos cuidadores. Con los datos obtenidos, se generaron modificaciones en aquellos ítems que obtuvieron una razón de validez de contenido menor a 0,49. Conclusión La versión obtenida en español de la resulta ser válida desde el punto de vista de su contenido y equivalente a su versión original.

Introduction It is estimated that by the year 2050, persons over 60 will account for 22% of the world population. Consequently, the incidence and prevalence of Alzheimer's disease will increase correspondingly. One of the pillars of the treatment of this condition is to improve the quality of life. In this sense, questionnaires such as the Quality of Life in Alzheimer's Disease allow us to measure the quality of life in patients and caregivers. Objective To translate into Chilean Spanish and carry out the content validation of the Quality of Life in Alzheimer's Disease scale in patients with Alzheimer's dementia at the Guillermo Grant Benavente Hospital in Concepción, Chile. Methods Translation, back-translation and content validity were carried out by expert judgment, using Lawshe analysis, pre-test and semantic validation using the respondent debriefing strategy. Results The translated and retranslated versions were compared with each other and with the original version. Lawshe indicates that a Content Validity Ratio equal 0.49 is adequate to consider the item valid when 15 experts participated in the content validation process, as in our study. The analysis yielded a content validity ratio greater than 0.49 in 11 of the 13 items on the scale. Of these, 8 obtained a value greater than 0.8 and 3 between 0.49 and 0.79. In semantic validation using the respondent debriefing strategy, the scale was applied to five people with Alzheimer's and their respective caregivers. With the data obtained, modifications were generated in those items that obtained a content validity ratio of less than 0.49. Conclusions The version obtained in Spanish of the Quality of Life in Alzheimer's Disease scale is valid from the point of view of its content and equivalent to its original version.

Violencia obstétrica en contexto de pandemia por COVID-19: una revisión de la literatura / Obstetric violence in the context of the COVID-19 pandemic: a literature review

INTRODUCCIÓN. Violencia obstétrica es entendida como aquella que ejerce el personal de salud sobre el cuerpo de las mujeres, expresada en un trato deshumanizado, un abuso de la medicalización y la patologización de los procesos naturales. OBJETIVO. Describir la violencia obstétrica en contexto de pandemia reportada en la literatura. MATERIAL Y MÉTODO. Se llevó a cabo una revisión sistematizada entre agosto y noviembre del año 2022. Los términos MeSH utilizados fueron "Obstetric violence", "Pandemic", "Birth" and "Human rights", junto con los términos DECS "Violencia obstétrica", "Pandemia", "Parto" y "Derechos humanos". En la totalidad de las bases de datos revisadas se aplicaron como límites de búsqueda "Last 3 Years" y "Free Full Text. RESULTADOS. Se constató un aumento de la violencia obstétrica dadas las adaptaciones en los protocolos de atención. Además, se evidenciaron formas de ejercerla tales como: restricción del acompañamiento, separación de la madre y recién nacido, aceleración del trabajo de parto, limitación de medidas farmacológicas, discriminación por raza/color y disminución en la frecuencia de controles y talleres prenatales. CONCLUSIÓN. La evidencia revisada sugiere que la violencia obstétrica durante la pandemia aumentó, siendo esta misma un factor influyente.

BACKGROUND. Obstetric violence is understood as violence exercised by health personnel on the body of women, expressed as dehumanized treatment, an abuse of medicalization and/or the pathologization of natural processes. OBJECTIVE. To describe obstetric violence in the context of a pandemic as reported in the literature. METHODS. A systematized review was conducted between August and November 2022. MeSH descriptors "Obstetric violence", "Pandemic" and "Human rights", along with DECS descriptors "Violencia obstétrica", "Pandemia", "Parto" and "Derechos humanos", were used. In all databases the search was limited to "Last 3 years" and "Free Full Text". RESULTS: An increase in obstetric violence was associated with adaptations in care protocols. The ways of exercising obstetric violence included: restriction of accompaniment, separation of mother and newborn, acceleration of labor, limitation of pharmacological measures, discrimination by race/color, and decrease in the frequency of prenatal controls and workshops. CONCLUSION: The reviewed evidence shows that obstetric violence during the pandemic increased, suggesting that the context was an influential factor.

Fármacos antiepilépticos usados en el embarazo y sus consecuencias sobre los resultados fetales: una revisión de la literatura / Antiepileptic drugs used in pregnancy and their consequences on fetal outcomes: a review of the literature

Los riesgos teratogénicos ocasionados por la exposición intrauterina a fármacos antiepilépticos (FAE) son conocidos, por lo que su prescripción se mantiene bajo estricto control. Describir los efectos adversos fetales de la exposición a FAE durante la gestación, reportados en la literatura durante el período 2016-2022. Revisión sistematizada de estudios que reportaron los efectos adversos fetales inducidos por la exposición a FAE en mujeres embarazadas en tratamiento por diagnósticos neurológicos, principalmente de epilepsia. La búsqueda se realizó en PubMed, Cochrane, Web of Science, SCOPUS, Biblioteca Virtual en Salud, Lilacs y SciELO. Se identificaron 37 artículos distribuidos en 13 países de Asia, Europa, América del Norte y Oceanía. Se observaron resultados perinatales adversos, tanto físicos como cognitivos, en la mayoría de los estudios. Los fármacos identificados como los más utilizados en los últimos años fueron valproato, topiramato, carbamazepina, lamotrigina y levetiracetam. Los FAE tienen potencial teratogénico en distintos grados de riesgo, provocando anomalías congénitas o efectos adversos en múltiples sistemas del cuerpo humano, siendo los sistemas nervioso, circulatorio y osteomuscular los más afectados.

The teratogenic risks caused by intrauterine exposure to antiepileptic drugs (AED) are known, so their prescription is kept under strict control. To describe the fetal adverse effects AED exposure during gestation, reported in the literature during the period 2016-2022. Systematized review of studies that reported fetal adverse effects induced for the exposure to AED in pregnant women in treatment for neurological diagnoses, mainly epilepsy. The search was carried out in PubMed, Cochrane, Web of Science, SCOPUS, Virtual Health Library, Lilacs and SciELO. 37 articles distributed in thirteen countries in Asia, Europe, North America and Oceania were identified. Adverse perinatal outcomes, both physical and cognitive, were observed in most studies. The most common drugs identified were valproate, topiramate, carbamazepine, lamotrigine and levetiracetam. AED have teratogenic potential in different degrees of risk, causing congenital anomalies or adverse effects in multiple systems of the human body, being the nervous, circulatory and musculoskeletal systems the most affected.

[Therapeutic plasma exchange. Experience in 102 patients]. / Intercambio plasmático terapéutico por plasmafiltración: experiencia de 11 años de un centro.

BACKGROUND: Therapeutic Plasma Exchange (TPE) is a procedure in which plasma and harmful macromolecules are separated from the rest of the blood components by centrifugation or filtration through membranes and are replaced with solutions with albumin and/or plasma. AIM: To communicate our experience using TPE by filtration. MATERIAL AND METHODS: Review of records of 655 TPE sessions performed in 102 patients aged 50 ± 18 years (64% women). The requirement of renal replacement therapy (RRT) and seven days and one year mortality were recorded. RESULTS: Forty five percent of patients had hypertension or diabetes. The main indications for TPE were pulmonary-renal syndrome (PRS) (62%) and antibody mediated graft rejection (29%), followed by neurological diseases (36%). Fifteen percent of patients required RRT for one year. Mortality at seven days and one year was 20 and 30%, respectively. Out of the total of deaths associated with kidney diseases, 88% corresponded to PRS and ANCA vasculitis. The main complications were thrombocytopenia in 41%, hypocalcemia in 18%, and hypotension in 16%. CONCLUSIONS: In our experience, TPE by filtration is a safe technique, with mild and preventable complications. Despite this, the reported mortality is high, which reflects the severity of the diseases that motivated the indication for TPE.

Percepción de las vías del parto de mujeres en edad reproductiva: una revisión de la literatura / Perception regarding the delivery routes of women in reproductive age: a literature review

OBJETIVO: Explorar la percepción de mujeres en edad reproductiva con respecto a las vías del parto reportada en la evidencia disponible. MÉTODO: Se llevó a cabo una revisión sistematizada de artículos en las bases de datos PubMed, SciELO, SCOPUS, Web of Science, LILACS, Cochrane Library y Biblioteca Virtual de Salud. La búsqueda se realizó entre agosto y noviembre del año 2020. Los términos MeSH usados fueron "Perception", "Delivery Obstetric", "Cesarean Section" y "Woman", junto con los términos DECS "Percepción", "Parto Obstétrico", "Cesárea" y "Mujeres". Además, se utilizaron los términos libres "Perceptions", "Vaginal Delivery", "Obstetric Deliveries", "Abdominal Deliveries", "Caesarean Section" y "Womens Groups". En la totalidad de las bases de datos utilizadas se aplicaron como límites de búsqueda "Last 5 Years" y "Free Full Text". RESULTADOS: Respecto a la percepción de las vías de parto, se constató la preferencia de la vía vaginal sobre la cesárea. Además, se evidenciaron factores que influyen en el proceso, tales como miedo, experiencia previa, influencia de terceros, religión, cultura, nivel socioeconómico y zona demográfica. CONCLUSIONES: La evidencia revisada sugiere que las mujeres prefieren la vía del parto vaginal sobre la cesárea, siendo el miedo el factor más influyente al momento de su elección, seguido por los factores asociados a experiencias previas, el nivel socioeconómico y las creencias.

OBJECTIVE: To explore the perception of women of reproductive age regarding delivery routes reported in the available evidence. METHOD: A systematized review of articles in PubMed, SciELO, SCOPUS, Web of Science, LILACS, Cochrane Library, Biblioteca Virtual de Salud databases, was carried out. The search was conducted between August and November 2020. MeSH descriptors "Perception", "Delivery Obstetric", "Cesarean Section" and "Woman", along with DECS descriptors "Percepciones", "Parto Obstétrico", "Cesárea" and "Mujeres", were used. Also, free terms "Perceptions", "Vaginal Delivery", "Obstetric Deliveries", "Abdominal Deliveries", "Caesarean Section" and "Womens Groups". In the totality of databases limits of search "Last 5 years" and "Free Full Text", were used. RESULTS: Regarding the perception of the delivery routes, the preference of the vaginal route over caesarean section was verified. In addition, factors that influence the process such as fear, previous experience, influence of third parties, religion, culture, socioeconomic level and demographic area were evidenced. CONCLUSIONS: The reviewed evidence suggests that women prefer the vaginal delivery route over caesarean section with fear being the most influential factor at the time of their choice, and secondly, the factors associated with previous experiences, socioeconomic level and beliefs.

Intercambio plasmático terapéutico por plasmafiltración: experiencia de 11 años de un centro / Therapeutic plasma exchange: experience in 102 patients

BACKGROUND: Therapeutic Plasma Exchange (TPE) is a procedure in which plasma and harmful macromolecules are separated from the rest of the blood components by centrifugation or filtration through membranes and are replaced with solutions with albumin and/or plasma. AIM: To communicate our experience using TPE by filtration. MATERIAL AND METHODS: Review of records of 655 TPE sessions performed in 102 patients aged 50 ± 18 years (64% women). The requirement of renal replacement therapy (RRT) and seven days and one year mortality were recorded. RESULTS: Forty five percent of patients had hypertension or diabetes. The main indications for TPE were pulmonary-renal syndrome (PRS) (62%) and antibody mediated graft rejection (29%), followed by neurological diseases (36%). Fifteen percent of patients required RRT for one year. Mortality at seven days and one year was 20 and 30%, respectively. Out of the total of deaths associated with kidney diseases, 88% corresponded to PRS and ANCA vasculitis. The main complications were thrombocytopenia in 41%, hypocalcemia in 18%, and hypotension in 16%. CONCLUSIONS: In our experience, TPE by filtration is a safe technique, with mild and preventable complications. Despite this, the reported mortality is high, which reflects the severity of the diseases that motivated the indication for TPE.

Calidad del sueño en estudiantes de medicina de la Universidad Andrés Bello, 2019, Chile / Sleep quality in medical students from Andrés Bello University, 2019, Chile

Resumen Introducción: El sueño es un estado fisiológico-rítmico que cursa con pérdida de conciencia y capacidad de respuesta. Durante este se llevan a cabo procesos imprescindibles para el aprendizaje y el metabolismo, por lo que cobra relevancia conservar una adecuada calidad del mismo. Objetivo: Describir la calidad del sueño de los estudiantes de medicina de la Universidad Andrés Bello sede Concepción, durante el primer semestre del año 2019. Métodos: Se realizó un estudio descriptivo de corte transversal con 147 estudiantes de primer a cuarto año de la carrera de medicina de la Universidad Andrés Bello sede Concepción. Los datos fueron levantados mediante el Índice de la Calidad de Sueño de Pittsburgh --ICSP--, y posteriormente procesados con el software IBM Statistics SPSS v.22. Resultados: El 91,8% de los estudiantes presentaron mala calidad de sueño (ICSP>5), con una puntuación promedio de 8,4. Los componentes con mayor variabilidad entre los cursos fueron la duración (p<0,01) y las perturbaciones del sueño (p<0,02). Por su parte, los estudiantes que trabajaban presentaron mayor presencia de perturbaciones del sueño en comparación con aquellos que solo se dedicaban a sus estudios (p=0,03). Conclusiones: Los estudiantes de la carrera de medicina de la Universidad Andrés Bello, sede Concepción, presentaron una mala calidad del sueño. Esto podría ser atribuido a la alta exigencia académica y/o a la carga horaria utilizada en clases teóricas y prácticas, y empeoraría al agregar exigencias adicionales como tener que trabajar durante los estudios. MÉD.UIS.2021;34(3): 29-38.

Abstract Background: Sleep is a critical physiological state, which occurs with loss of consciousness and response capacity. During this, essential processes for learning and metabolism are carried out, so it is important to preserve adequate sleep quality. Aim: To describe the sleep quality of medical students at Andrés Bello University, Concepción headquarter, during the first half of 2019. Methods: A descriptive cross-sectional study was carried out with 147 students from the first to fourth year of the medical career at Andrés Bello University, Concepción headquarter. Data was collected using the Pittsburgh Sleep Quality Index --ICSP--, and later processed with IBM Statistics SPSS v.22 software. Results: 91,8% of students showed poor sleep quality (ICSP> 5), with average score of 8,4. Components with mayor variability between courses were duration (p<0,01) and sleep disturbances (p<0,02). For their part, students who were working had mayor presence of sleep disturbances compared to those who only dedicated themselves to their studies (p=0,03). Conclusions: The surveyed students reported poor sleep hygiene. This could be attributed to the high academic demand and / or the time load used in theoretical and practical classes, and it would be made worse by adding additional demands such as having to work during studies. As a future projection, longitudinal follow-up of the students would be recommended, which would allow evaluating the impact that different variables such as stress, evaluations, variations in the number of subjects and semester clinical hours, among others, would have on the sleep quality of the students. MED.UIS.2021;34(3): 29-38.

Conocimiento de la anticoncepción de emergencia en mujeres adolescentes de enseñanza media de la comuna de Hualqui, Chile / Emergency contraception knowledge in female adolescent secondary education students from Hualqui commune, Chile

INTRODUCCIÓN Dado que el conocimiento sobre la anticoncepción de emergencia puede ser de gran utilidad en la promoción de la salud sexual y salud reproductiva, especialmente en los adolescentes, la deficiencia del mismo podría disminuir su prescripción y uso. OBJETIVO Describir el conocimiento sobre los métodos anticonceptivos de emergencia de un grupo de mujeres adolescentes estudiantes de enseñanza media de la comuna de Hualqui, Chile. MATERIAL Y MÉTODO Se realizó un estudio descriptivo de corte transversal. Se encuestó a 115 mujeres adolescentes estudiantes de primer a cuarto año de enseñanza media del liceo San Juan Bautista de Hualqui, Octava Región de Chile. Se exploraron antecedentes generales de salud sexual y salud reproductiva, y conocimientos sobre la anticoncepción de emergencia, su uso y formas de adquisición. RESULTADOS La edad promedio fue de 16,1 años. El 39% de las estudiantes eran sexualmente activas, y en promedio iniciaron su vida sexual a los 15,3 años y tuvieron 2,1 parejas sexuales. El método anticonceptivo que más utilizaban fue el anticonceptivo hormonal inyectable (31,1%), seguido de la anticoncepción oral combinada (20,0%). Con respecto a la anticoncepción de emergencia, el 80,9% declaró saber de su entrega liberada, mientras que el 11,1% declaró haberlos usado alguna vez. El 91,3% de las encuestadas consideró necesario tener mayor información. CONCLUSIÓN Las adolescentes participantes del estudio mostraron algún grado de conocimiento respecto a la anticoncepción de emergencia, pese a no utilizarla habitualmente. No obstante, la mayoría expresó la necesidad de tener mayor acceso a información relacionada al tema.

BACKGROUND Given that knowledge about emergency contraception can be very useful in promoting sexual health and reproductive health, especially in adolescents, its deficiency could decrease its prescription and use. AIM To describe the knowledge about emergency contraceptive methods of a group of female adolescent secondary education students from the Hualqui commune, Chile. METHOD A descriptive cross-sectional study was carried out. 115 adolescent women students from first to fourth year of high school at San Juan Bautista high school in Hualqui, Eighth Region of Chile, were surveyed. General sexual health and reproductive health backgrounds, and knowledge of emergency contraception, its use, and forms of acquisition were explored. RESULTS The average age was 16,1 years. 39% of the students were sexually active, and on average started their sex life at 15,3 years and had 2,1 sexual partners. The most widely used contraceptive method was injectable hormonal contraception (31,1%), followed by combined oral contraception (20,0%). Regarding the emergency contraception, 80,9% stated that they knew of their free delivery, while 11,1% stated that they had ever used them. 91,3% of respondents considered it necessary to have more information. CONCLUSIONS The adolescents participating in the study showed some degree of knowledge regarding emergency contraception, despite not using it regularly. However, the majority expressed the need for greater access to information related to the topic.

[Bilateral renal papillary necrosis of spontaneous resolution as a cause of microscopic hematuria. Report of one case]. / Necrosis papilar renal bilateral de resolución espontánea como causa de hematuria microscópica. Caso clínico.

Renal papillary necrosis is an infrequent cause of hematuria characterized by ischemic necrosis of the renal medulla, especially the papilla. Its most common cause is analgesic abuse. Despite being oligo-symptomatic, in many cases its presence is associated with serious functional sequelae. Imaging, especially computed tomography, is essential to make the diagnosis. We report a 63-year-old female studied for an asymptomatic microscopic hematuria whose tomographic study showed a bilateral renal papillary necrosis. No etiology was found, and she evolved with a spontaneous complete remission.

[Coronary artery disease in pre and postmenopausal women. The influence of type 2 diabetes mellitus]. / Enfermedad coronaria en mujeres pre y postmenopáusicas y su relación con la diabetes mellitus tipo 2.

BACKGROUND: Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor. AIM: To assess the severity of CHD in pre and postmenopausal patients undergoing coronary angiography and the impact of T2DM in both groups. MATERIAL AND METHODS: A coronary angiography was performed to 707 women due to suspected CHD during 2013 and 2014. Of these, 579 were older than 55 years and were considered as postmenopausal. Factors such as hypertension, obesity, smoking, creatinine and T2DM were registered. The severity of CHD in coronary angiography was evaluated according to the number of vessels with more than 50% stenosis. RESULTS: Compared to their postmenopausal counterparts, premenopausal women had less frequency of T2DM (31% and 42% p < 0.033), hypertension (52 and 78%, p < 0.001) and alteration of renal function (11 vs. 39%, p < 0.001). Absence of coronary lesions was found in 44 and 32% of premenopausal and postmenopausal women, respectively (p < 0.01). Premenopausal women with T2DM had a higher frequency of multi-vessel disease than those without the disease (25 and 4.5%, p < 0.001). The frequency of multi-vessel disease was higher in postmenopausal than premenopausal women (24 and 11%, p < 0.01). Hypertension, T2DM and renal involvement were associated with a higher frequency multiple vessel disease. CONCLUSIONS: The severity of CHD is higher in postmenopausal women and T2DM is associated with the disease.

Factores asociados a respuesta favorable de tratamiento corticoidal en pacientes con polirradiculoneuropatía desmielinizante inflamatoria crónica / Variables associated with a good response to steroids in chronic inflammatory demyelinating polyradiculoneuropathy

Background: The treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is based on corticosteroids, immunoglobulin and plasmapheresis. In our Health System, corticosteroids are commonly used as first line therapy for economic reasons and accessibility. However, the factors associated with a good response are not well known. Aim: To assess the association of demographic, clinical and laboratory variables with a favorable response to corticosteroid therapy in patients with CIDP. Material and Methods: Observational, descriptive, longitudinal and retrospective study of 33 patients with a diagnosis of typical, definitive or probable CIDP, treated with corticosteroids for at least six months. Results: Twenty-three patients had a good clinical response to corticosteroid treatment and 10 were non-responders. The variables significantly associated with a good response to steroids were a disease lasting less than 1 year prior to the start of treatment, the absence of axonal damage in electromyography a relapsing-recurrent course and a favorable response within two months of treatment. Conclusions: Most of these patients with CIDP had good response to corticosteroid therapy.

Enfermedad coronaria en mujeres pre y postmenopáusicas y su relación con la diabetes mellitus tipo 2 / Coronary artery disease in pre and postmenopausal women. The influence of type 2 diabetes mellitus

Background: Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor. Aim: To assess the severity of CHD in pre and postmenopausal patients undergoing coronary angiography and the impact of T2DM in both groups. Material and Methods: A coronary angiography was performed to 707 women due to suspected CHD during 2013 and 2014. Of these, 579 were older than 55 years and were considered as postmenopausal. Factors such as hypertension, obesity, smoking, creatinine and T2DM were registered. The severity of CHD in coronary angiography was evaluated according to the number of vessels with more than 50% stenosis. Results: Compared to their postmenopausal counterparts, premenopausal women had less frequency of T2DM (31% and 42% p < 0.033), hypertension (52 and 78%, p < 0.001) and alteration of renal function (11 vs. 39%, p < 0.001). Absence of coronary lesions was found in 44 and 32% of premenopausal and postmenopausal women, respectively (p < 0.01). Premenopausal women with T2DM had a higher frequency of multi-vessel disease than those without the disease (25 and 4.5%, p < 0.001). The frequency of multi-vessel disease was higher in postmenopausal than premenopausal women (24 and 11%, p < 0.01). Hypertension, T2DM and renal involvement were associated with a higher frequency multiple vessel disease. Conclusions: The severity of CHD is higher in postmenopausal women and T2DM is associated with the disease.

Necrosis papilar renal bilateral de resolución espontánea como causa de hematuria microscópica. Caso clínico / Bilateral renal papillary necrosis of spontaneous resolution as a cause of microscopic hematuria. Report of one case

Renal papillary necrosis is an infrequent cause of hematuria characterized by ischemic necrosis of the renal medulla, especially the papilla. Its most common cause is analgesic abuse. Despite being oligo-symptomatic, in many cases its presence is associated with serious functional sequelae. Imaging, especially computed tomography, is essential to make the diagnosis. We report a 63-year-old female studied for an asymptomatic microscopic hematuria whose tomographic study showed a bilateral renal papillary necrosis. No etiology was found, and she evolved with a spontaneous complete remission.

[Variables associated with a good response to steroids in chronic inflammatory demyelinating polyradiculoneuropathy]. / Factores asociados a respuesta favorable de tratamiento corticoidal en pacientes con polirradiculoneuropatía desmielinizante inflamatoria crónica.

BACKGROUND: The treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is based on corticosteroids, immunoglobulin and plasmapheresis. In our Health System, corticosteroids are commonly used as first line therapy for economic reasons and accessibility. However, the factors associated with a good response are not well known. AIM: To assess the association of demographic, clinical and laboratory variables with a favorable response to corticosteroid therapy in patients with CIDP. MATERIAL AND METHODS: Observational, descriptive, longitudinal and retrospective study of 33 patients with a diagnosis of typical, definitive or probable CIDP, treated with corticosteroids for at least six months. RESULTS: Twenty-three patients had a good clinical response to corticosteroid treatment and 10 were non-responders. The variables significantly associated with a good response to steroids were a disease lasting less than 1 year prior to the start of treatment, the absence of axonal damage in electromyography a relapsing-recurrent course and a favorable response within two months of treatment. CONCLUSIONS: Most of these patients with CIDP had good response to corticosteroid therapy.